Engineering antibody affinity and specif
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D. M. Webster; S. Roberts; J. C. Cheetham; R. Griest; A. R. Rees
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Article
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1988
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John Wiley and Sons
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French
โ 375 KB
A combination of ab initio calculations, "knowledge-based prediction", molecular graphics and site-directed mutagenesis has enabled us to probe the molecular details of antibody:antigen recognition and binding and to alter the affinity and specificity of an antibody for its antigen. The significance