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Wortmannin, a myosin light chain kinase inhibitor of microbial orgin

โœ Scribed by Satoshi Nakanishi; Shingo Kakita; Isami Takahashi; Kiyotaka Kawahara; Eiji Tsukuda; Tomoyuki Sano; Koji Yamada; Mayumi Yoshida; Hiroshi Kase; Yuzuru Matsuda; Yoshiaki Hashimoto; Yoshiaki Nonomura

Book ID
115984084
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
81 KB
Volume
24
Category
Article
ISSN
0022-2828

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Effects of a myosin light chain kinase i
Effects of a myosin light chain kinase inhibitor, wortmannin, on cytoplasmic Ca2+levels, myosin light chain phosphorylation and force in vascular smooth muscle
โœ Makoto Takayama; Hiroshi Ozaki; Hideaki Karaki ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 870 KB

Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat