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Wnt3a regulates tumor necrosis factor-α-stimulated interleukin-6 release in osteoblasts

✍ Scribed by Hideo Natsume; Haruhiko Tokuda; Seiji Adachi; Rie Matsushima-Nishiwaki; Kenji Kato; Chiho Minamitani; Takanobu Otsuka; Osamu Kozawa


Book ID
116734874
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
555 KB
Volume
331
Category
Article
ISSN
0303-7207

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## Abstract Inflammatory cytokines are well known to play crucial roles in the pathogenesis of rheumatoid arthritis. Among them, interleukin (IL)‐17 is a cytokine that is mainly synthesized by activated T cells and its receptors are present in osteoblasts. The synthesis of IL‐6, known to stimulate