Leukemias and lymphoid diseases as only Williams can cover them Featuring content derived from Williams Hematology, Ninth Edition. this concise, full-color resource delivers comprehensive and current coverage of leukemias and lymphoid diseases. More than a sectional reprint, the book includes upda
Williams Hematology: The Red Cell and Its Diseases
โ Scribed by Josef Prchal, Marshall Lichtman
- Publisher
- McGraw Hill / Medical
- Year
- 2021
- Tongue
- English
- Leaves
- 575
- Edition
- 1
- Category
- Library
No coin nor oath required. For personal study only.
โฆ Synopsis
Everything you need to know about red cell disorders, from basic science to clinical application.
When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the bodyโas a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies.
The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care.
This comprehensive, yet concise resource covers:
- Structure and physiology of the red cell
- Classification of red cell diseases
- Diseases of red cell production
- Anemias resulting principally from inherited disorders
- Anemia as a result of exogenous factors
- Polyclonal erythrocytosis
- Red cell transfusion
โฆ Table of Contents
Cover
WilliamsHematology The Red Cell and Its Diseases
Cover Image Desctription
Title
Copyright
Contributors
Preface
Part I Structure and Physiology of the Red Cell
STRUCTURE AND COMPOSITION OF THE ERYTHROCYTE*
SUMMARY
ERYTHRON
REFERENCES
ERYTHROPOIESIS AND RED CELL TURNOVER
SUMMARY
HISTORY
PHYLOGENY OF RED CELL PRODUCTION
ONTOGENY OF RED CELL PRODUCTION
CELLULAR COMPONENTS OF ERYTHROPOIESIS AND ITS REGULATION
RED CELL LIFE SPAN
REMOVAL OF ERYTHROCYTE ORGANELLES
MICRORNAS (miRNAS) IN ERYTHROPOIESIS
MEASUREMENTS OF RED CELL MASS
MEASUREMENTS OF RED CELL PRODUCTION
MECHANISMS OF DESTRUCTION OF ABNORMAL RED BLOOD CELLS
FATE OF HEMOGLOBIN IN INTRAVASCULAR DESTRUCTION
REFERENCES
Part II Classification of Red Cell Diseases
CLINICAL MANIFESTATIONS AND CLASSIFICATION OF ERYTHROCYTE DISORDERS
SUMMARY
ANEMIA
ERYTHROCYTOSIS
REFERENCES
PART III Diseases of Red Cell Production
APLASTIC ANEMIA: ACQUIRED AND INHERITED
SUMMARY
INTRODUCTION ACQUIRED APLASTIC ANEMIA
ETIOLOGY AND PATHOGENESIS
HEREDITARY APLASTIC ANEMIA
OTHER INHERITED APLASTIC ANEMIAS
REFERENCES
PURE RED CELL APLASIA
SUMMARY
CONSTITUTIONAL PURE RED CELL APLASIA (DIAMOND-BLACKFAN ANEMIA)
INTRODUCTION
TRANSIENT APLASTIC CRISIS AND TRANSIENT ERYTHROBLASTOPENIA OF CHILDHOOD
ACQUIRED PURE RED CELL APLASIA
REFERENCES
ANEMIA OF CHRONIC DISEASE
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
CLINICAL FEATURES
LABORATORY FEATURES
HYPOFERREMIA AND DECREASED SERUM TRANSFERRIN
DIFFERENTIAL DIAGNOSIS
THERAPY, COURSE, AND PROGNOSIS
REFERENCES
ERYTHROPOIETIC EFFECTS OF ENDOCRINE DISORDERS
SUMMARY
THYROID DYSFUNCTION
ADRENAL GLAND DISORDERS
GONADAL HORMONES
PITUITARY GLAND DISORDERS
HYPERPARATHYROIDISM
REFERENCES
PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
CLINICAL FEATURES
LABORATORY FEATURES
DIFFERENTIAL DIAGNOSIS
THERAPY
REFERENCES
FOLATE, COBALAMIN, AND MEGALOBLASTIC ANEMIAS
SUMMARY
FOLATE
COBALAMIN
MEGALOBLASTIC ANEMIAS
REFERENCES
IRON METABOLISM
SUMMARY
INTRODUCTION
DISTRIBUTION OF IRON IN THE AVERAGE PERSON
DIETARY IRON
IRON ABSORPTION
REFERENCES
IRON DEFICIENCY AND OVERLOAD
SUMMARY
IRON DEFICIENCY
IRON STORAGE DISEASE
REFERENCES
ANEMIA RESULTING FROM OTHER NUTRITIONAL DEFICIENCIES
SUMMARY
VITAMIN-DEFICIENCY ANEMIAS
INTRODUCTION
TRACE METAL DEFICIENCY
ANEMIA OF STARVATION
ANEMIA OF PROTEIN DEFICIENCY (KWASHIORKOR)
ALCOHOLISM
REFERENCES
ANEMIA ASSOCIATED WITH MARROW INFILTRATION
SUMMARY
ETIOLOGY AND PATHOGENESIS
DEFINITION AND HISTORY
CLINICAL FEATURES
LABORATORY FEATURES
DIFFERENTIAL DIAGNOSIS
THERAPY, COURSE, AND PROGNOSIS
REFERENCES
Part IV Anemias Resulting Principally from Inherited Disorders
THE HEREDITARY DYSERYTHROPOIETIC ANEMIAS
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
CONGENITAL DYSERYTHROPOIETIC ANEMIA, TYPE I
CONGENITAL DYSERYTHROPOIETIC ANEMIA, TYPE II
GENETICS
TREATMENT, COURSE, AND PROGNOSIS
CONGENITAL DYSERYTHROPOIETIC ANEMIA, TYPE III
OTHER CONGENITAL DYSERYTHROPOIETIC ANEMIAS
DIFFERENTIAL DIAGNOSIS
REFERENCES
ERYTHROCYTE MEMBRANE DISORDERS
SUMMARY
INTRODUCTION
OVERVIEW OF THE ERYTHROCYTE MEMBRANE
COMPONENTS OF THE ERYTHROCYTE MEMBRANE
MEMBRANE ORGANIZATION
CELLULAR DEFORMABILITY AND MEMBRANE STABILITY
MEMBRANE PERMEABILITY
ERYTHROCYTE MEMBRANE DISORDERS
REFERENCES
ERYTHROCYTE ENZYME DISORDERS
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
CLINICAL FEATURES
LABORATORY FEATURES
DIFFERENTIAL DIAGNOSIS
THERAPY
COURSE AND PROGNOSIS
REFERENCES
THALASSEMIA: A DISORDER OF GLOBIN SYNTHESIS
SUMMARY
DEFINITIONS AND HISTORY
EPIDEMIOLOGY AND POPULATION GENETICS
ETIOLOGY AND PATHOGENESIS
MOLECULAR BASIS OF THE THALASSEMIAS
PATHOPHYSIOLOGY
CLINICAL FEATURES
LABORATORY FEATURES AND DIFFERENTIAL DIAGNOSIS OF THE THALASSEMIA SYNDROMES
THERAPY, COURSE, AND PROGNOSIS
PROGNOSIS
NOVEL THERAPEUTIC APPROACHES
THALASSEMIA AS A GLOBAL HEALTH PROBLEM
PREVENTION
REFERENCES
DISORDERS OF HEMOGLOBIN STRUCTURE: SICKLE CELL ANEMIA AND OTHER HEMOGLOBINOPATHIES
SUMMARY
THE STRUCTURE AND FUNCTION OF NORMAL HEMOGLOBIN
NOMENCLATURE OF ABNORMAL HEMOGLOBINS
SICKLE CELL DISEASE
OTHER ABNORMAL HEMOGLOBINS
REFERENCES
METHEMOGLOBINEMIA AND OTHER DYSHEMOGLOBINEMIAS
SUMMARY
METHEMOGLOBINEMIA
SULFHEMOGLOBIN
LOW-OXYGEN AFFINITY HEMOGLOBINS: A CAUSE OF CYANOSIS
OTHER DYSHEMOGLOBINS
NITRIC OXIDE AND NITRIC OXIDE HEMOGLOBINS
REFERENCES
POLYCLONAL AND HEREDITARY SIDEROBLASTIC ANEMIAS
SUMMARY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
DEFINITION AND HISTORY
CLINICAL AND LABORATORY FEATURES
TREATMENT
REFERENCES
THE PORPHYRIAS
SUMMARY
DEFINITION AND HISTORY
ETIOLOGY AND PATHOGENESIS
ERYTHROPOIETIC PORPHYRIAS
ACUTE PORPHYRIAS
REFERENCES
Part V Anemia as a Result of Exogenous Factors
FRAGMENTATION HEMOLYTIC ANEMIA
SUMMARY
PREECLAMPSIA OR ECLAMPSIA AND HELLP SYNDROME
DISSEMINATED MALIGNANCY
HEART VALVE HEMOLYSIS
OTHER CAUSES OF NONIMMUNE HEMOLYSIS
REFERENCES
ERYTHROCYTE DISORDERS AS A RESULT OF TOXIC AGENTS
SUMMARY
ERYTHROCYTE TOXINS ACTING THROUGH WELL-DEFINED MECHANISMS
ERYTHROCYTE TOXINS ACTING THROUGH INCOMPLETELY DEFINED MECHANISMS
REFERENCES
HEMOLYTIC ANEMIA RESULTING FROM INFECTIONS WITH MICROORGANISMS
SUMMARY
MALARIA
BARTONELLOSIS (OROYA FEVER)
BABESIOSIS
CLOSTRIDIUM PERFRINGENS SEPTICEMIA
OTHER INFECTIONS
REFERENCES
HYPERSPLENISM AND HYPOSPLENISM
SUMMARY
HYPERSPLENISM
HYPOSPLENISM
REFERENCES
HEMOLYTIC ANEMIA RESULTING FROM IMMUNE INJURY
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
CLINICAL FEATURES
LABORATORY FEATURES
DIFFERENTIAL DIAGNOSIS
THERAPY
COURSE AND PROGNOSIS
REFERENCES
ALLOIMMUNE HEMOLYTIC DISEASE OF THE FETUS AND NEWBORN
SUMMARY
EPIDEMIOLOGY
CLINICAL FEATURES OF HEMOLYTIC DISEASE OF THE FETUS AND NEWBORN
PATHOPHYSIOLOGY
ANTENATAL MONITORING
THERAPY
OUTCOME
PREVENTION
CONCLUSIONS
REFERENCES
Part VI Polyclonal Erythrocytosis
PRIMARY AND SECONDARY ERYTHROCYTOSES (POLYCYTHEMIAS)
SUMMARY
DEFINITION AND HISTORY
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
CLINICAL FEATURES
LABORATORY FEATURES
SECONDARY ERYTHROCYTOSIS
DIFFERENTIAL DIAGNOSIS
ERYTHROCYTOSES OTHER THAN POLYCYTHEMIA VERA
COURSE AND PROGNOSIS
REFERENCES
Part VII Red Cell Transfusion
ERYTHROCYTE ANTIGENS AND ANTIBODIES
SUMMARY
DEFINITIONS AND HISTORY
BLOOD GROUP SYSTEMS
ANTIGEN EXPRESSION
BIOCHEMISTRY OF ERYTHROCYTE ANTIGENS
EFFECT OF ENZYMES AND OTHER CHEMICALS ON ERYTHROCYTE ANTIGENS
GENETICS OF ERYTHROCYTE ANTIGENS
RED CELL ANTIGENS IN HEALTH AND DISEASE
ASSOCIATIONS OF RED CELL ANTIGENS WITH DISEASE
ERYTHROCYTE ANTIBODIES
CLINICAL SIGNIFICANCE OF ERYTHROCYTE ANTIBODIES
SEROLOGIC DETECTION OF ERYTHROCYTE ANTIGENS AND ANTIBODIES
REFERENCES
BLOOD PROCUREMENT AND RED CELL TRANSFUSION
SUMMARY
OVERVIEW OF THE BLOOD SUPPLY SYSTEM IN THE UNITED STATES
INTERNATIONAL PRACTICES
PROCUREMENT OF PLASMA DERIVATIVES
RECRUITMENT OF BLOOD DONORS
WHOLE-BLOOD DONOR SCREENING
COLLECTION OF WHOLE BLOOD
BLOOD COMPONENTS
SPECIAL BLOOD DONATIONS
COLLECTION AND PRODUCTION OF BLOOD COMPONENTS BY APHERESIS
SELECTION OF APHERESIS DONORS
REACTIONS IN APHERESIS DONORS
LABORATORY TESTING OF DONATED BLOOD
SAFETY OF THE BLOOD SUPPLY
RED CELL TRANSFUSIONS
HEMOGLOBINOPATHIES
HEMATOPOIETIC STEM CELL TRANSPLANT
SOLID-ORGAN TRANSPLANT
ADVERSE EFFECTS OF TRANSFUSIONS
POTENTIAL EFFECT OF AGE OF RED CELLS ON TRANSFUSION OUTCOME
PATIENT BLOOD MANAGEMENT
REFERENCES
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