Red Cell Membrane Transport in Health and Disease

✍ Scribed by Cees W. M. Haest (auth.), Professor Dr. Ingolf Bernhardt, Professor Dr. J. Clive Ellory (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2003
Tongue: English
Leaves: 760
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book describes our current understanding of the transport of ions, amino acids, nucleosides, sugars, water and gases across the red blood cell membrane. It also outlines the necessary theoretical background to understand the dynamics of membrane constituents together with the mechanisms of transport pathways (pumps, channels, carriers/cotransporters, residual passive permeability). Separate chapters describe our present ideas about membrane and metabolic disorders as well as red blood cell diseases like malaria, sickle cell disease, and hypertension. The latest findings are explained on the basis of a historical review and well-established principles. The book and its chapters are thus structured in a manner that makes the material accessible to beginners in the field of red blood cell physiology and biophysics. Active researchers will also benefit from this carefully organized compilation.

✦ Table of Contents

Front Matter....Pages I-XXVIII
Distribution and Movement of Membrane Lipids....Pages 1-25
Membrane Lipids and Proteins as a Basis of Red Cell Shape and its Alterations....Pages 27-60
Human Red Cell Shape and the Mechanical Characteristics of the Membrane....Pages 61-82
Passive Membrane Permeability for Ions and the Membrane Potential....Pages 83-109
Na + /K + Pump....Pages 111-137
Ion Channels....Pages 139-152
The Swelling-Sensitive Osmolyte Channel....Pages 153-171
Na + -K + -2Cl - Cotransport....Pages 173-195
K + -Cl - Cotransport in Vertebrate Red Cells....Pages 197-220
The Band 3 Protein: Anion Exchanger and Anion-Proton Cotransporter....Pages 221-252
Band 3 Mediated Transport....Pages 253-301
Amino Acid Transport....Pages 303-319
Equilibrative Nucleoside Transport Proteins....Pages 321-337
Glucose Transport....Pages 339-372
Calcium Homeostasis in Normal and Abnormal Human Red Cells....Pages 373-405
Magnesium Transport....Pages 407-434
Trace Metal Transport....Pages 435-450
Monocarboxylate and other Organic Anion Transport....Pages 451-476
Water Permeability....Pages 477-488
Gas Transport....Pages 489-509
‘The Hereditary Stomatocytosis and Allied Conditions’: Inherited Disorders Na + and K + Transport....Pages 511-523
Metabolic Disorders....Pages 525-548
Sickle Cell Disease....Pages 549-567
The Membrane Physiology of the ‘Malaria-Infected’ Red Cell....Pages 569-585
Hypertension....Pages 587-602
Disorders of Band 3....Pages 603-619
Amino Acid Transport in Disease....Pages 621-642
Transgenic Models of Red Cell Disorders....Pages 643-671
Red Cell Ageing....Pages 673-690
Active and Passive Monovalent Ion Transport Association with Membrane Antigens in Sheep Red Cells: a Molecular Riddle....Pages 691-720
Comparative Physiology of Red Cell Membrane Transport....Pages 721-734
Back Matter....Pages 735-748

✦ Subjects

Biophysics and Biological Physics;Life Sciences, general;Biomedicine general;Hematology

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