The Red Cell Membrane: A Model for Solute Transport

✍ Scribed by H. J. Schatzmann (auth.), B. U. Raess, Godfrey Tunnicliff (eds.)

• Publisher: Humana Press
• Year: 1990
• Tongue: English
• Leaves: 478
• Series: Contemporary Biomedicine 10
• Edition: 1
• Category: Library

✦ Synopsis

"After being frequently urged to write upon this subject, and as often declining to do it, from apprehension of my own inability, I am at length compelled to take up the pen, however unqualified I may still feel myself for the task. " William Withering, M. D. ' I have yet to find a description or a quote that better summanzes my initial ambivalence towards embarking on such an endeavor as partici­ pating in putting together this monograph. The impetus for The Red-Cell has been a simple, genuine Membrane: A Model for Solute Transport desire to bring together an authoritative account of the' 'state of the art and knowledge" in the red-ceIl-membrane transport field. In particular, it seems important to emphasize the pivotal role the red cell has played for several decades in the discovery and the elucidation of mechanisms of plasma-membrane transport processes. It is only with such knowledge that we can hope to push ahead and make progress in this exciting, multifaceted area. Eventually, one hopes to not only further our knowledge of red cells, but apply the newly gained insights to any other of the plasma membrane. cell with the common denominator In this compendium of reviews, the reader will find that the term model will take on a variety of gists and meanings. In some chapters, the red cell has been chosen as a model membrane solely on the basis of its preeminent design and simplicity.

✦ Table of Contents

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Why Red Cells?....Pages 3-17
Need and Applications of Integrated Red Cell Models....Pages 19-34
Front Matter....Pages 35-35
The Molecular Structure of the Na,K-ATPase....Pages 37-54
Enzymatic and Functional Aspects of Na + /K + Transport....Pages 55-73
The (Ca 2+ + Mg 2+ )-ATPase....Pages 75-101
Catalytic Mechanisms of the Ca-Pump ATPase....Pages 103-121
Regulation of the Plasma Membrane Ca 2+ -Pump....Pages 123-142
The Anion Transport Protein....Pages 143-170
Kinetics of Anion Transport....Pages 171-200
Ca 2+ -Activated Potassium Channels....Pages 201-231
Amino Acid Flux Across the Human Red Cell Plasma Membrane....Pages 233-247
Hexose Transport Across Human Erythrocyte Membranes....Pages 249-279
Chloride-Dependent Cation Transport in Human Erythrocytes....Pages 281-302
Front Matter....Pages 303-303
Pharmacological Modification of the Red Cell Ca 2+ -Pump....Pages 305-327
Irreversible Modification of the Anion Transporter....Pages 329-367
Drug Actions on Potassium Fluxes in Red Cells....Pages 369-396
Front Matter....Pages 397-397
Membrane Lipid Changes in the Abnormal Red Cell....Pages 399-421
Calcium Fluxes in Pathologically Altered Red Cells....Pages 423-442
Mechanisms of Red Cell Dehydration in Sickle Cell Anemia....Pages 443-461
Back Matter....Pages 463-475

✦ Subjects

Human Physiology