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WID, a novel negative regulator of the WNT signaling pathway, is important for kidney development

✍ Scribed by Myong Shin Kim; Jirouta Kitagaki; Frank Bollig; Christoph Englert; Alan O. Perantoni; Sean B. Lee


Book ID
116977617
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
58 KB
Volume
331
Category
Article
ISSN
0012-1606

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Members of the Wnt family of secreted glycoproteins act as short-range signaling molecules in vertebrate embryogenesis. Previous work has shown that Wnt-4 is required for kidney development. Mice lacking functional Wnt-4 fail to form pretubular cell aggregates. Wnt-4 acts as an autoinducer of the me