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Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration

✍ Scribed by Zhang, F.; Tagen, M.; Throm, S.; Mallari, J.; Miller, L.; Guy, R. K.; Dyer, M. A.; Williams, R. T.; Roussel, M. F.; Nemeth, K.; Zhu, F.; Zhang, J.; Lu, M.; Panetta, J. C.; Boulos, N.; Stewart, C. F.

Book ID: 121677701
Publisher: American Society for Pharmacology and Experimental Therapeutics
Year: 2010
Tongue: English
Weight: 840 KB
Volume: 39
Category: Article
ISSN: 0090-9556
DOI: 10.1124/dmd.110.035915

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## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F