𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

✍ Scribed by Malmborg, Jonas; Ploeger, Bart A.


Book ID
123441577
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
557 KB
Volume
67
Category
Article
ISSN
1056-8719

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Investigation of 5-FU disposition after
✍ Yuko Tsukamoto; Yukio Kato; Masako Ura; Ikuo Horii; Tohru Ishikawa; Hideo Ishits 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 2 views

## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F