Cytogenetic analysis of one case of acute myeloid leukemia (AML), one of acute lymphoblastic leukemia (ALL), one of refractory anemia with excess of blasts (RAEB), and one of acute mixed lineage leukemia (AMLL) with unbalanced 7;12 translocations mapped the breakpoints to the centromeres on both chr
Whole arm translocations in solid tumors and hematologic malignancy — formation and clinical significance
✍ Scribed by K.E. Richkind; C. Lytle; A. Lamb; J. Velasco; S. Roherty
- Book ID
- 114136713
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 129 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0165-4608
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Jumping translocations (JTs) and segmental jumping translocations (SJTs) are unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to multiple recipient chromosomes. In leukemia, where JTs have been predominantly observed, the donor segment (usually 1q) pref
If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy