White matter lesions in spastic paraplegia
✍ Scribed by Vera Peterová
- Book ID
- 116793906
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 114 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0960-8966
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## Abstract Hereditary spastic paraplegias (HSP) are genetically and clinically heterogeneous neurodegenerative disorders. Most MR studies on HSP include very heterogeneous samples of patients, and findings were inconsistent. Here, we examined six patients with pure HSP and SPG4 mutations by clinic
A family is described with 5 males in a single generation affected with a previously undescribed complicated form of hereditary spastic paraparesis (HSP). The disease is characterized by speech difficulties, lower limb spasticity and hyper-reflexia, mental retardation, cerebellar ataxia, and tremor.