Which target for DBS in Parkinson's disease? Subthalamic nucleus versus globus pallidus internus
โ Scribed by A. E. Scotto di Luzio; F. Ammannati; P. Marini; S. Sorbi; P. Mennonna
- Publisher
- Springer Milan
- Year
- 2001
- Tongue
- English
- Weight
- 33 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1590-1874
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## Abstract Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN s
We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was weari