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What Is the Role of the Helical Domain of Gs α in the GTPase Reaction? †

✍ Scribed by Shnerb, Tamar; Lin, Naama; Shurki, Avital

Book ID
127058259
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
278 KB
Volume
46
Category
Article
ISSN
0006-2960

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## Abstract G‐protein α subunits consist of two domains: a Ras‐like domain also called GTPase domain (GTPaseD), structurally homologous to monomeric G‐proteins, and a more divergent domain, unique to heterotrimeric G‐proteins, called helical domain (HD). G‐protein activation, requires the exchange

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The G␣ subunits of heterotrimeric G proteins are constituted by a conserved GTPase ''Ras-like '' domain (RasD) and by a unique ␣-helical domain (HD). Upon GTP binding, four regions, called switch I, II, III, and IV, have been identified as undergoing structural changes. Switch I, II, and III are loc