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Role of the Buried Glutamate in the α-Helical Coiled Coil Domain of the Macrophage Scavenger Receptor

✍ Scribed by Suzuki, Kazuo; Yamada, Tomoko; Tanaka, Toshiki

Book ID
126092346
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
226 KB
Volume
38
Category
Article
ISSN
0006-2960

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To determine when secondary structure forms as two chains coalesce to form an alpha-helical dimer, the folding rates of variants of the coiled coil region of GCN4 were compared. Residues at non-perturbing positions along the exterior length of the helices were substituted one at a time with alanine