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What Is the Correct Value for the Brain-Blood Partition Coefficient for Water?

✍ Scribed by Herscovitch, Peter; Raichle, Marcus E.


Book ID
109869673
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
261 KB
Volume
5
Category
Article
ISSN
0271-678X

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It is shown that log P values for water-alkane or water-cyclohexane partitions, and the corresponding Delta log P values when used as descriptors for blood-brain distribution, as log BB, yield equations with very poor correlation coefficients but very good standard deviations, S from 0.25 to 0.33 lo

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## Abstract We describe the use of relative proton density imaging to obtain spatially resolved measurements of the brain:blood partition coefficient for water. Values of relative proton density and apparent‐T1 were calculated by performing a multidimensional nonlinear least squares fit of progress