What is the clinical impact of occult hepatitis B virus infection?
β Scribed by Giovanni Raimondo; Teresa Pollicino; Giovanni Squadrito
- Book ID
- 117287872
- Publisher
- The Lancet
- Year
- 2005
- Tongue
- English
- Weight
- 51 KB
- Volume
- 365
- Category
- Article
- ISSN
- 0140-6736
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Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also
## Abstract Although occult hepatitis B virus (HBV) infection (HBVβDNA in serum in the absence of hepatitis B surface antigen [HBsAg]) is common in chronic hepatitis C, its characteristics are not well known. In this work, the presence of HBVβDNA (by polymerase chain reaction; PCR) and its distribu