Impact of occult hepatitis B virus infection on the outcome of chronic hepatitis C
β Scribed by Squadrito, Giovanni; Cacciola, Irene; Alibrandi, Angela; Pollicino, Teresa; Raimondo, Giovanni
- Book ID
- 121192064
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 623 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Although occult hepatitis B virus (HBV) infection (HBVβDNA in serum in the absence of hepatitis B surface antigen [HBsAg]) is common in chronic hepatitis C, its characteristics are not well known. In this work, the presence of HBVβDNA (by polymerase chain reaction; PCR) and its distribu
Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also