What is migraine? Controversy and stalemate in migraine pathophysiology
β Scribed by J. Edmeads
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 395 KB
- Volume
- 238
- Category
- Article
- ISSN
- 0340-5354
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Migraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with
## Abstract ## Objectives: We investigated the prevalence of migraine in patients with patent foramen ovale (PFO), and the effect of PFO closure on migraine symptoms and medications. ## Background: Studies have shown an association between migraine and PFO. Data have recently suggested a reducti
Familial hemiplegic migraine (FHM) is a severe subtype of migraine with hemiparesis during attacks. We scanned 10 families with FHM without mutations in the CACNA1A (FHM1) and ATP1A2 (FHM2) genes. We identified the novel p.L1649Q mutation (c.4946T>A) in Na(v)1.1 sodium channel gene SCN1A (FHM3) in a