What causes the enhancement of activity of factor VIIa by tissue factor?
β Scribed by C. M. COLINA; D. VENKATESWARLU; R. DUKE; L. PERERA; L. G. PEDERSEN
- Book ID
- 109151811
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 309 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1538-7933
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Tissue factor (TF), a transmembrane glycoprotein, functions as an essential activator of the serine protease factor Vlla. This enzymatic complex is considered to be the principal initiator of in vivo coagulation. Recent studies emphasize the role of the TF/Vlla complex in a number of pathophysiologi
Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor Vlla complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the development of an amidine based linker which allowed th
The characteristics of a phospholipid surface are of major importance in the activation of factor X in the presence of tissue factor-factor VIIa (TF-VIIa) complex. A possible tool which provides a measure of the surface corrugation and roughness is the fractal dimension analysis. This paper uses the