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Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa–tissue factor

✍ Scribed by M. NDONWI; G. BROZE JR


Book ID
109152538
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
157 KB
Volume
6
Category
Article
ISSN
1538-7933

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Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor Vlla complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the development of an amidine based linker which allowed th