Wet sol–gel derived silica for controlled release of proteins
✍ Scribed by Deborah Teoli; Laura Parisi; Nicola Realdon; Massimo Guglielmi; Antonio Rosato; Margherita Morpurgo
- Book ID
- 113691348
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 867 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0168-3659
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## Abstract Silica xerogels doped with diclofenac diethylamine were prepared by the sol–gel method from a hydrolysed tetraethoxysilane (TEOS) solution containing diclofenac diethylamine. Two different catalysts, drying conditions and levels of water content were used to alter the microstructure of
Controlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parame