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Sol–gel processed porous silica carriers for the controlled release of diclofenac diethylamine

✍ Scribed by Katarzyna Czarnobaj; Joanna Czarnobaj

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
199 KB
Volume
87B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Silica xerogels doped with diclofenac diethylamine were prepared by the sol–gel method from a hydrolysed tetraethoxysilane (TEOS) solution containing diclofenac diethylamine. Two different catalysts, drying conditions and levels of water content were used to alter the microstructure of the silica xerogels. The aim of this study was to determine the rate of Diclofenac release from the silica xerogels. This in vitro study showed that the sol–gel method is useful for entrapping Diclofenac in the pores of xerogels. It also showed that, in vitro, Diclofenac is released from the silica xerogel, through the pores, by diffusion. Base‐catalysed gels proved to be much more effective than acid‐catalyzed gels. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008

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