Well-differentiated endocrine pancreatic tumour and Wernicke's encephalopathy
✍ Scribed by Solange Grunenwald; Stéphanie Broussaud; Delphine Vezzosi; Antoine Bennet; Vincent Larrue; Philippe Caron
- Book ID
- 108704204
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 73 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0300-0664
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## Abstract Well‐differentiated neuroendocrine tumors (WDNT, carcinoid tumors) are uncommon indolent neoplasms. The genetic alterations of these tumors are not well characterized. We used genome‐wide high‐density single nucleotide polymorphism (SNP) array analysis to detect copy number alterations
Two molecular pathways leading to cancer are known. Common-type cancers arise from the 'tumour suppressor' pathway, characterized by gross chromosomal changes and allelic losses (LOH) in an average of 25 per cent or more of randomly chosen chromosomal loci. The 'mutator pathway' has been recognized