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Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)

✍ Scribed by Choi, In-Seon; Estecio, Marcos R H; Nagano, Yasuhiko; Kim, Do Ha; White, Jill A; Yao, James C; Issa, Jean-Pierre J; Rashid, Asif


Book ID
109889595
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
193 KB
Volume
20
Category
Article
ISSN
0893-3952

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## Abstract Well‐differentiated neuroendocrine tumors (WDNT, carcinoid tumors) are uncommon indolent neoplasms. The genetic alterations of these tumors are not well characterized. We used genome‐wide high‐density single nucleotide polymorphism (SNP) array analysis to detect copy number alterations

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Background. The immunoreactivity for progesterone receptors (PR) of the majority of endocrine cells of the human pancreas has prompted the authors to investigate if PR expression is maintained in pancreatic endocrine tumors and is correlated with the main clinicopathologic features of these neoplasm