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Weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in hormone-refractory prostate cancer: In vitro combined effects and a Phase II trial

✍ Scribed by Chia-Chi Lin; Chih-Hung Hsu; Tzyh-Chyuan Hour; Ann-Lii Cheng; Chao-Yuan Huang; Kuo-How Huang; Jun Chen; Yeong-Shiau Pu

Book ID
116955957
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
161 KB
Volume
25
Category
Article
ISSN
1078-1439

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer