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Weak Base Dispiro-1,2,4-trioxolanes: Potent Antimalarial Ozonides.

✍ Scribed by Jonathan L. Vennerstrom; et al. et al.


Book ID
102001920
Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

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The iron-mediated reactivity of various dispiro-1,2,4-trioxolanes was determined by automated kinetic analysis under standard reaction conditions. The active antimalarial compounds underwent peroxide bond cleavage by Fe(II) resulting in products indicative of carbon-centered radical formation. The r