A model of pattern formation in the early embryo is presented. It is motivated by the necessary interaction of kinases and phosphatases, and in particular by the family of Wnt kinase and RPTP phosphatase signaling pathways. It is seen as complementary to the more short-range patterning of the Delta/
Waves of Pattern Formation and Signal Pathways
β Scribed by F.W. Cummings
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 92 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0022-5193
No coin nor oath required. For personal study only.
β¦ Synopsis
The model addresses the question of the origin of traveling waves, mimicking waves of the Hh and Dpp proteins, such as found in development of the fly eye. These two proteins, which are part of an important signaling pathway to the genome, are found in a diverse array of developmental situations, for example in the formation of proximal-distal axes in limbs. The complex intracellular biochemistry involved is modeled in the simplest way in both cases, with the intent that concepts be emphasized over biochemical detail.
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