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Water-soluble polysaccharides as carriers of paramagnetic contrast agents for magnetic resonance imaging: Synthesis and relaxation properties

✍ Scribed by P»l Rongved; Jo Klaveness

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
739 KB
Volume
214
Category
Article
ISSN
0008-6215

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✦ Synopsis

Water-soluble, carbohydrate-based, paramagnetic metal chelate derivatives have been investigated as potential organ-selective contrast media for magnetic resonance imaging (m.r.i.). The in vitro proton spin-lattice relaxation properties of compounds with different paramagnetic metals, chelating agents, and carbohydrate matrixes have been studied. Typically, these complexes were 60-260% more efficient proton-relaxation agents than the corresponding low-molecular-weight metal chelates at 10 MHz, but less efficient than the corresponding protein derivatives. As expected, carbohydrates that contained manganese or gadolinium were more effective relaxation agents than iron, copper, erbium, or nickel derivatives.

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