Cross-linked, degradable starch microspheres as carriers of paramagnetic contrast agents for magnetic resonance imaging: Synthesis, degradation, and relaxation properties

✍ Scribed by P»l Ronved; Bernt Lindberg; Jo Klaveness

• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 445 KB
• Volume: 214
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(91)80039-p

✦ Synopsis

Biodegradable particles were produced by the cross-linking of starch with epichlorohydrin. Diethylenetriaminepenta-acetic acid (DTPA) was covalently linked to the particles by using DTPA bisanhydride. The small, gadolinium-labelled particles were 40-260% more efficient in vitro proton relaxation agents than the corresponding unbound chelate gadolinium-DTPA. The relaxation properties were dependent on the metal chelate, the particle size, the metal content, and the degree of substitution (d.s.). For the small gadolinium-DTPA particles, an increased d.s. decreased the rate of degradation by alpha-amylase.