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Water proton NMR relaxation mechanisms in lung tissue

✍ Scribed by M. Kveder; I. Zupančič; G. Lahajnar; R. Blinc; D. Šuput; D. C. Ailion; K. Ganesan; C. Goodrich

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
536 KB
Volume
7
Category
Article
ISSN
0740-3194

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✦ Synopsis

The NMR relaxation times T i , T2, and TI were measured in isolated rat lungs as functions of external magnetic field Bo, temperature, and lung inflation. The observed linear dependence on Bo of the tissue-induced free induction decay rate (Tb)-' provides independent confirmation of the air/water interface model of the lung. Furthermore, measurements of the Larmor frequency dependence of T, are consistent with a spin-lattice relaxation rate of the form I/Tl = Aw-'" + B as expected for the case in which the relaxation arises from water-biopolymer cross-relaxation, which should be proportional to the surface area of the lung. This prediction was verified by observations of an approximately linear dependence of 1/T, on transpulmonary pressure and thus on the lung surface area.

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