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Water diffusion anisotropy in white and gray matter of the human spinal cord

✍ Scribed by Cristina Rossi; Andreas Boss; Günter Steidle; Petros Martirosian; Uwe Klose; Silvia Capuani; Bruno Maraviglia; Claus D. Claussen; Fritz Schick

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
1002 KB
Volume
27
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To develop a reliable technique for diffusion imaging of the human spinal cord at 1.5 Tesla and to assess potential differences in diffusion anisotropy in cross‐sectional images.

Materials and Methods

A single‐shot echo‐planar imaging sequence with double spin‐echo diffusion preparation was optimized regarding cerebrospinal fluid artifacts, effective resolution, and contrast‐to‐noise ratios. Eleven healthy volunteers participated in the study for quantitative characterization of diffusion anisotropy in white matter (WM) and gray matter (GM) by means of two diffusion encoding schemes: octahedral‐six‐directions for fractional anisotropy (FA) evaluation and orthogonal‐three‐directions for anisotropy index (AI) calculation.

Results

Pulse‐trigger gated sequences with optimal matrix size (read × phase = 64 × 32) and b‐value (700 s/mm^2^) allowed the acquisition of high‐resolved images (voxel size = 0.9 × 0.9 × 5.0 mm^3^). The GM butterfly shape was recognizable in both AI and FA maps. Both encoding schemes yielded high diffusion anisotropy in dorsal WM (FA = 0.79 ± 0.07; AI = 0.39 ± 0.04). Lateral WM showed slightly lower anisotropy (FA = 0.69 ± 0.08; AI = 0.35 ± 0.03) than dorsal WM. Clearly smaller anisotropy was found in regions containing GM (FA = 0.45 ± 0.06; AI = 0.21 ± 0.05).

Conclusion

Diffusion anisotropy data of the spinal cord can be obtained in a clinical setting. Its application seems promising for the assessment of neurological disorders. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.

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