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Developmental apoptosis in the spinal cord white matter in neonatal rats

✍ Scribed by A.J.A. De Louw; W.D.J. Van De Berg; J. De Vente; C.E. Blanco; A.W.D. Gavilanes; H.P.J. Steinbusch; H.W.M. Steinbusch; J. Troost; J.S.H. Vles

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
204 KB
Volume
37
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

We investigated developmental apoptosis in the white matter of the cervical spinal cord at postnatal days 2, 5, and 8. Apoptotic cells were labeled using TUNEL and caspase‐3 immunostaining. Apoptotic cells were diffusely distributed throughout the white matter of the spinal cord. The total amount of apoptotic cells in the cervical spinal cord white matter was related to postnatal age, with the lowest at P2 (mean 7.9, SD 5.6) and the highest at P8 (mean 109, SD 21.4). Using double immunostaining for ED‐1 and O4, apoptotic cells were identified as microglia and oligodendrocytes. GLIA 37:89–91, 2002. Β© 2002 Wiley‐Liss, Inc.

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