Background: Corticosteroids (CS) effectively induce remission in patients with moderate to severe Crohn's disease (CD). However, CS dependence in children is a significant clinical problem associated with numerous side effects. Identification of molecular markers of CS dependence is of paramount imp
β¦ LIBER β¦
W1243 Associations Between Genetic Variants in MDR1/ABCB1 Gene and Corticosteroid Dependency in Paediatric Crohn's Disease Patients
β Scribed by Krupoves, Alfreda; Mack, David R.; Levy, Emile; Deslandres, Colette; Lambrette, Philippe; Feguery, Houda H.; Dong, Jinsong; Bucionis, Vytautas; Seidman, Ernest G.; Amre, Devendra K.
- Book ID
- 122450489
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 80 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0016-5085
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## Background: Genomewide linkage studies identified chromosome 3p21 as an ibd locus. genomewide association studies have supported this locus and the wellcome trust case control consortium (wtccc) study narrowed it to a 0.6 mb region. our objectives were to perform a 2-stage candidate gene associa