Voriconazole-related photosensitivity in CF patients is associated with ΔF508/ΔF508 genotype
✍ Scribed by S. Rondeau; L. Couderc; S. Dominique; S. Pramil; C. Leguillon; B. Masseline; C. Marguet
- Book ID
- 118642894
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 36 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1569-1993
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Analysis of a sample of 50 unrelated cystic fibrosis (CF) patients and 46 nuclear families from Slovakia (Czechoslovakia) by the polymerase chain reaction and Southern hybridization revealed that the proportion of the delta F508 mutation was 58% in this population, and that the frequency of the B (i
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. The disease can be caused by one of the more than 900 different mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. However, the deletion of the phe508-codon is the most pre