Volume change on formation of native collagen aggregate
β Scribed by James M. Cassel; Richard G. Christensen
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1967
- Tongue
- English
- Weight
- 379 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
β¦ Synopsis
The volume change which orcws in dilute tropocollagen solution as R result of the phase transition producing the "native" form of collagen aggregate has been measured dilatometrically. A volume increase of 0.8 X 10-3 ml./g. collagen in phosphate buffer (pH 7-7.5) was determined. The volume expansion is attributed to a reduction in the organization of water molecules around nonpolar surfaces of the individual tropocollagen units. This volume expansion is consistent with a previous hypothesis that hydrophobic bonding is the driving force in this collagen aggregation.
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