Voltage-gated Sodium Channels: Structure, Function and Channelopathies

✍ Scribed by Mohamed Chahine

Publisher: Springer International Publishing
Year: 2018
Tongue: English
Leaves: 448
Series: Handbook of Experimental Pharmacology 246
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

✦ Table of Contents

Front Matter ....Pages i-x
Front Matter ....Pages 1-1
Evolutionary History of Voltage-Gated Sodium Channels (Atsuo Nishino, Yasushi Okamura)....Pages 3-32
Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits (Steven Molinarolo, Daniele Granata, Vincenzo Carnevale, Christopher A. Ahern)....Pages 33-49
Front Matter ....Pages 51-51
Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective (Tamer M. Gamal El-Din, Michael J. Lenaeus, William A. Catterall)....Pages 53-72
The Cardiac Sodium Channel and Its Protein Partners (Elise Balse, Catherine Eichel)....Pages 73-99
Posttranslational Modification of Sodium Channels (Zifan Pei, Yanling Pan, Theodore R. Cummins)....Pages 101-124
Sodium Channel Trafficking (A. Mercier, P. Bois, A. Chatelier)....Pages 125-145
pH Modulation of Voltage-Gated Sodium Channels (Colin H. Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C. Ruben)....Pages 147-160
Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C (Ademuyiwa S. Aromolaran, Mohamed Chahine, Mohamed Boutjdir)....Pages 161-184
Front Matter ....Pages 185-185
Toxins That Affect Voltage-Gated Sodium Channels (Yonghua Ji)....Pages 187-207
Mechanisms of Drug Binding to Voltage-Gated Sodium Channels (M. E. O’Leary, M. Chahine)....Pages 209-231
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels (Alessandro Farinato, Concetta Altamura, Jean-François Desaphy)....Pages 233-250
Structural Models of Ligand-Bound Sodium Channels (Boris S. Zhorov)....Pages 251-269
Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 (Jian Payandeh, David H. Hackos)....Pages 271-306
Front Matter ....Pages 307-307
Sodium Channelopathies of Skeletal Muscle (Stephen C. Cannon)....Pages 309-330
Cardiac Arrhythmias Related to Sodium Channel Dysfunction (Eleonora Savio-Galimberti, Mariana Argenziano, Charles Antzelevitch)....Pages 331-354
Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain (Katrin Schrenk-Siemens, Corinna Rösseler, Angelika Lampert)....Pages 355-369
Gating Pore Currents in Sodium Channels (J. R. Groome, A. Moreau, L. Delemotte)....Pages 371-399
Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells (Bela Joos, Benjamin M. Barlow, Catherine E. Morris)....Pages 401-422
Voltage-Gated Sodium Channel β Subunits and Their Related Diseases (Alexandra A. Bouza, Lori L. Isom)....Pages 423-450

✦ Subjects

Biomedicine; Pharmacology/Toxicology; Human Genetics; Human Physiology; Protein Structure

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