Voltage Gated Sodium Channels

✍ Scribed by Peter C. Ruben (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2014
• Tongue: English
• Leaves: 295
• Series: Handbook of Experimental Pharmacology 221
• Edition: 1
• Category: Library

✦ Synopsis

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

✦ Table of Contents

Front Matter....Pages i-viii
Introduction to Sodium Channels....Pages 1-6
The Voltage Sensor Module in Sodium Channels....Pages 7-31
Slow Inactivation of Na + Channels....Pages 33-49
The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels....Pages 51-89
Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents....Pages 91-110
Regulation/Modulation of Sensory Neuron Sodium Channels....Pages 111-135
The Role of Late I Na in Development of Cardiac Arrhythmias....Pages 137-168
Proton Modulation of Cardiac I Na : A Potential Arrhythmogenic Trigger....Pages 169-181
Probing Gating Mechanisms of Sodium Channels Using Pore Blockers....Pages 183-201
Animal Toxins Influence Voltage-Gated Sodium Channel Function....Pages 203-229
Ubiquitylation of Voltage-Gated Sodium Channels....Pages 231-250
Pharmacological Insights and Quirks of Bacterial Sodium Channels....Pages 251-267
Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels....Pages 269-291
Back Matter....Pages 293-295

✦ Subjects

Pharmacology/Toxicology; Neurosciences; Cardiology; Membrane Biology; Protein Structure