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Voclosporin (ISA247) for plaque psoriasis – Authors' reply

✍ Scribed by Kim A Papp; Neil H Shear; Robert B Huizinga; Walter P Maksymowych

Book ID
117303604
Publisher
The Lancet
Year
2008
Tongue
English
Weight
51 KB
Volume
372
Category
Article
ISSN
0140-6736

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✍ Kuglstatter, Andreas ;Mueller, Francis ;Kusznir, Eric ;Gsell, Bernard ;Stihle, M 📂 Article 📅 2011 🏛 International Union of Crystallography 🌐 English ⚖ 469 KB

X-ray crystal structures of the cyclosporin A analogue __E__-ISA247 (voclosporin) and its stereoisomer __Z__-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.