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Vitamin D Intake Is Negatively Associated with Promoter Methylation of the Wnt Antagonist Gene DKK1 in a Large Group of Colorectal Cancer Patients

✍ Scribed by Rawson, James B.; Sun, Zhouyu; Dicks, Elizabeth; Daftary, Darshana; Parfrey, Patrick S.; Green, Roger C.; Gallinger, Steven; McLaughlin, John R.; Wang, Peizhong P.; Knight, Julia A.; Bapat, Bharati


Book ID
127367888
Publisher
Lawrence Erlbaum Associates, Inc.
Year
2012
Tongue
English
Weight
136 KB
Volume
64
Category
Article
ISSN
0163-5581

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Promoter methylation of the Wnt/Ξ²-cateni
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## Abstract ## BACKGROUND: Abnormal activation of the Wnt/β‐catenin signaling pathway is common and critical in the pathogenesis of digestive cancers. In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene __Dkk‐3__ in these cancers and its prognostic signi