Vital Rates from the Action of Mutation Accumulation
โ Scribed by Kenneth W. Wachter; David R. Steinsaltz; Steven N. Evans
- Book ID
- 107592819
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 535 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1874-7884
No coin nor oath required. For personal study only.
โฆ Synopsis
New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus.
๐ SIMILAR VOLUMES
Recent attempts to estimate mutation rates in man have resulted in some theoretical developments. Recently, Nei (1977) provided a new formula for estimating mutation rates from electrophoretically detected rare protein variants. His formula is applied here to estimated mutation rates from such varia