Point mutations, as well as additions or deletions of entire domains, are frequently produced to study protein function; however, to infer function from mutant proteins, it is imperative that their structural integrity be verified. Although detailed structural studies can be performed by using NMR o
โฆ LIBER โฆ
Mutation rates from rare variants of proteins in Indian tribes
โ Scribed by Ranajit Chakraborty; Arun K. Roychoudhury
- Book ID
- 104708623
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 294 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0340-6717
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โฆ Synopsis
Recent attempts to estimate mutation rates in man have resulted in some theoretical developments. Recently, Nei (1977) provided a new formula for estimating mutation rates from electrophoretically detected rare protein variants. His formula is applied here to estimated mutation rates from such variants among the Kadars of Kerala and five tribes of Andhra Pradesh in India. The estimates seem to differ from Nei's estimate on South American Indians by an order of magnitude, although the standard errors associated with such estimates are rather large.
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