The in vivo mechanism of regulatory T cell (T(reg) cell) function in controlling autoimmunity remains controversial. Here we have used two-photon laser-scanning microscopy to analyze lymph node priming of diabetogenic T cells and to delineate the mechanisms of T(reg) cell control of autoimmunity in
โฆ LIBER โฆ
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
โ Scribed by Tang, Qizhi; Adams, Jason Y; Tooley, Aaron J; Bi, Mingying; Fife, Brian T; Serra, Pau; Santamaria, Pere; Locksley, Richard M; Krummel, Matthew F; Bluestone, Jeffrey A
- Book ID
- 109923197
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 945 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni1289
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Interface hepatitis, the histological lesion typical of autoimmune hepatitis (AIH), is composed of CD4 and CD8 T lymphocytes and of innate immunity cells, particularly monocytes. Studies in AIH have focused on autoreactive CD4 and CD8 T cells and impairment of CD4ุCD25ุ regulatory T cells (T-regs),