𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Virus infections and recurrence of osteosarcoma in patients receiving human leukocyte interferon

✍ Scribed by Snorri Ingimarsson; Gun Carlström; Kari Cantell; Hans Strander

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
483 KB
Volume
26
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human leukocyte interferon was given as adjuvant treatment for osteosarcoma in 26 patients. Blood from these patients was studied at regular intervals for antibodies to various micro‐organisms. A continuous record of clinically manifest infections during the course of interferon therapy was made in 23 of the 26 patients. Distant metastases arose in 14 patients ‐ the metastasis group. The report presents comparisons between these patients and the non‐metastasis group. Seroconversion in tests with any of the studied micro‐organisms was not common. Most of the seroconversions were not associated with clinical symptoms. Seroconversion during interferon therapy was confined to patients in the metastasis group. In some cases there was a chronologic link with early evidence of metastasis. The results of the serologic investigations are discussed and are correlated to the course of interferon therapy and of the neoplastic disease.

📜 SIMILAR VOLUMES

Interferon and spontaneous cytotoxicity
Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon
✍ Stefan Einhorn; Henric Blomgren; Hans Strander 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 866 KB

## Abstract The effect of daily injections of 3 × 10^6^ units of human leukocyte IF on the spontaneous cytotoxicity of peripheral lymphocytes was studied in 43 patients with a variety of diseases. An increase in spontaneous cytotoxicity was observed 12 to 24 h after the first IF injection with the

Immunespecific interferon production by
Immunespecific interferon production by peripheral blood mononuclear leukocytes from patients with primary and recurrent orolabial herpes simplex virus infections
✍ Jon A. Green; Paul N. Weiss; Tze-Jou Yeh; Spotswood L. Spruance 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

Imrnunespecific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95 % of HSV-seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 19811. However, herpes virus-induced immunespecific IFN was produced by PBML from only

Correlation of molecular human leukocyte
Correlation of molecular human leukocyte antigen typing and outcome in high-risk melanoma patients receiving adjuvant interferon
✍ Helen Gogas; John M. Kirkwood; Christine S. Falk; Urania Dafni; Vernon K. Sondak 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract ## BACKGROUND: Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously sho

Production of interferon alpha and inter
Production of interferon alpha and interferon gamma by peripheral blood leukocytes from patients with chronic hepatitis B virus infection
✍ Dr. Jochen Abb; Vera Zachoval; Friedrich Deinhardt; Gerd R. Pape; Reinhart Zacho 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 1 views

Peripheral blood leukocytes from patients with chronic hepatitis B virus (HBV) infection were studied for their capacity to produce interferon (IFN) alpha or IFN gamma. Yields of IFN alpha in leukocyte cultures stimulated with influenza A virus or human leukemic cells were significantly lower than t

Effect of human leukocyte interferon on
Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture
✍ Hans Strander; Stefan Einhorn 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 396 KB 👁 1 views

## Abstract Nine osteosarcoma cell lines, originally developed from six osteosarcoma tumours in five patients, and two cell lines of non‐tumour origin (glia and fibro‐blast) were grown __in vitro__ in the presence of human leukocyte interferon (L‐IF). L‐IF exerted a dose‐dependent inhibition of gro