Proteasome inhibitors have been shown to increase adeno-associated virus (AAV)-mediated transduction in vitro and in vivo. To assess if proteasome inhibitors also increase lipid-mediated gene transfer with relevance to cystic fibrosis (CF), we first assessed the effects of doxorubicin and N-acetyl-l
β¦ LIBER β¦
Viral gene transfer in neuroscience: new tricks of the trade
β Scribed by Sergey Kasparov; Julian F. R. Paton
- Book ID
- 110109713
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 31 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0958-0670
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## Abstract ## Background Stability, integrity and retention of the DNA within the targeted tissue is decisive for efficient gene transfer using naked DNA. Preβclinical and clinical studies require reproducible transfection rates by preventing rapid degradation of naked DNA in the transduced tissu