Viral covalently closed circular DNA in a non-transgenic mouse model for chronic hepatitis B virus replication
β Scribed by Tetsuo Takehara; Takahiro Suzuki; Kazuyoshi Ohkawa; Atsushi Hosui; Masahisa Jinushi; Takuya Miyagi; Tomohide Tatsumi; Yoshiyuki Kanazawa; Norio Hayashi
- Book ID
- 116650867
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 392 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Epigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription. The aim of this study was to compare the methylation status of the intrahepatic covalently closed circular DNA (cccDNA) CpG island 2 and HBV replication capability. HBV cccDNA was
## Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) serves as a template for viral replication and plays a role in persistence of HBV infection. The origin and significance of cccDNA in plasma however, is not well understood. A sensitive, specific, and reproducible realβtime