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O.1.1 Development of a new real-time PCR for the detection of covalently closed circular DNA (cccDNA) in plasma of chronic hepatitis B patients

✍ Scribed by R.B. Takkenberg; H.L. Zaaijer; S. Menting; V. Terpstra; C.J. Weegink; M.G.W. Dijkgraaf; P.L.M. Jansen; H.W. Reesink; M.G.H.M. Beld

Book ID: 117771019
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 158 KB
Volume: 44
Category: Article
ISSN: 1386-6532
DOI: 10.1016/s1386-6532(08)00457-5

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## Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) serves as a template for viral replication and plays a role in persistence of HBV infection. The origin and significance of cccDNA in plasma however, is not well understood. A sensitive, specific, and reproducible real‐time

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