Quantitation of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) in the liver of HBV-infected patients by LightCycler™ real-time PCR
✍ Scribed by Madhu Singh; Annie Dicaire; Adil E Wakil; Carolyn Luscombe; Stephen L Sacks
- Book ID
- 113766784
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 170 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0166-0934
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## Abstract Epigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription. The aim of this study was to compare the methylation status of the intrahepatic covalently closed circular DNA (cccDNA) CpG island 2 and HBV replication capability. HBV cccDNA was
## Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) serves as a template for viral replication and plays a role in persistence of HBV infection. The origin and significance of cccDNA in plasma however, is not well understood. A sensitive, specific, and reproducible real‐time