Many attempts have been made to elucidate the structure of viomycin, P strongly basic tuberculostatic streptomyces antibiotic (l-7). These studies led Bowie, CoX,Johnson and Thomas (6) tc present I and more recently Dyer, Kellogg, Nassar and Streetman (7) to propose II as the structure of viomycin.
Viomycin: II. The structure of viomycin
โ Scribed by John R. Dyer; C.K. Kellogg; R.F. Nassar; Wm.E. Streetman
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- French
- Weight
- 300 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0040-4039
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Bcceived 2 Uarch 1961) Acid hydrolysis of the strongly basic tuberculostatic antibiotic, vionycin 1.2 is known to yield L-swine, L-a~-diaminopropionic acid, L-B-lysine, carbon dioxide, ammonia, urea and a guanido compound. In a recent paper, 3IV er and hi8 collerguo~ suggeatad that the guanido compo
The peptide antibiotic viomycin at a concentration of 10 muM inhibits E. coli ribosomes to the extent of about 70% as measured in the poly (U) system, and to about 85% in a natural mRNA (R17) system. Ribosomes from M. smegmatis show no activity at all at this concentration of the antibiotic. Experim