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Vinylogous Amide Analogues of Diaminopimelic Acid (DAP) as Inhibitors of Enzymes Involved in Bacterial Lysine Biosynthesis

โœ Scribed by Caplan, Jennifer F.; Zheng, Renjian; Blanchard, John S.; Vederas, John C.


Book ID
120335208
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
110 KB
Volume
2
Category
Article
ISSN
1523-7060

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A key step in the diamitqimelate (DAP) pathway to L-lysine ( 7) involves condensation of pyruvate with aspattic acid g-semialdehyde (1) to yield L-2,3-dihydnxhpicolinic acid (2) (DHDPA) catalyzed by DHDPA thase.