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Pyridine and piperidine derivatives as inhibitors of dihydrodipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to l-lysine

✍ Scribed by Lynda Couper; John E. McKendrick; David J. Robins; Ewan J.T. Chrystal


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
412 KB
Volume
4
Category
Article
ISSN
0960-894X

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✦ Synopsis


A key step in the diamitqimelate (DAP) pathway to L-lysine ( 7) involves condensation of pyruvate with aspattic acid g-semialdehyde (1) to yield L-2,3-dihydnxhpicolinic acid (2) (DHDPA) catalyzed by DHDPA thase.